Macroalgae Extracts From Antarctica Have Antimicrobial and Anticancer Potential

نویسندگان

  • Rosiane M. Martins
  • Fernanda Nedel
  • Victoria B. S. Guimarães
  • Adriana F. da Silva
  • Pio Colepicolo
  • Claudio M. P. de Pereira
  • Rafael G. Lund
چکیده

Background: Macroalgae are sources of bioactive compounds due to the large number of secondary metabolites they synthesize. The Antarctica region is characterized by extreme weather conditions and abundant aggregations of macroalgae. However, current knowledge on their biodiversity and their potential for bio-prospecting is still fledging. This study evaluates the antimicrobial and cytotoxic activity of different extracts of four macroalgae (Cystosphaera jacquinotii, Iridaea cordata, Himantothallus grandifolius, and Pyropia endiviifolia) from the Antarctic region against cancer and non-cancer cell lines. Methods: The antimicrobial activity of macroalgae was evaluated by the broth microdilution method. Extracts were assessed against Staphylococcus aureus ATCC 19095, Enterococcus faecalis ATCC 4083, Escherichia coli ATCC29214, Pseudomonas aeruginosa ATCC 9027, Candida albicans ATCC 62342, and the clinical isolates from the human oral cavity, namely, C. albicans (3), C. parapsilosis, C. glabrata, C. lipolytica, and C. famata. Cytotoxicity against human epidermoid carcinoma (A-431) and mouse embryonic fibroblast (NIH/3T3) cell lines was evaluated with MTT colorimetric assay. Results: An ethyl acetate extract of H. grandifolius showed noticeable antifungal activity against all fungal strains tested, including fluconazole-resistant samples. Cytotoxicity investigation with a cancer cell line revealed that the ethyl acetate extract of I. cordata was highly cytotoxic against A-431 cancer cell line, increasing the inhibitory ratio to 91.1 and 95.6% after 24 and 48 h exposure, respectively, for a concentration of 500 μg mL-1. Most of the algal extracts tested showed little or no cytotoxicity against fibroblasts. Conclusion: Data suggest that macroalgae extracts from Antarctica may represent a source of therapeutic agents. HIGHLIGHTS Different macroalgae samples from Antarctica were collected and the lyophilized biomass of each macroalgae was extracted sequentially with different solventsThe antimicrobial and anticancer potential of macroalgae extracts were evaluatedEthyl acetate extract of H. grandifolius showed noticeable antifungal activity against all the fungal strains tested, including fluconazole-resistant samplesEthyl acetate extract of I. cordata was highly cytotoxic against the A-431 cancer cell lineMost of the algal extracts tested showed little or no cytotoxicity against normal cell lines.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Marine macroalgae with antioxidant, antimicrobial and cytotoxic potential

In the present investigation the acetone extracts of three marine macroalgae Laurentia obtusa, Codium elongatum and Cutleria multifida were tested for antioxidant, antimicrobial and cytotoxic potential. Antioxidant activity was evaluated by free radical scavenging, superoxide anion radical scavenging and reducing power. C. elongatum extract had most potent free radical scavenging activity (IC50...

متن کامل

Evaluation and comparison of antimicrobial and anticancer effects of aqueous and ethanolic extracts of violet

many medical properties including antimicrobial, anticancer, antioxidant, anti-inflammatory, etc. have been mentioned for Viola odorata. results have shown the solid cell-killing effects of Viola odorata cycloidal compounds. In addition, Pathogen resistance has necessitated the study of new antimicrobial compounds. This study aimed to evaluate the antimicrobial and anticancer effects of aqueous...

متن کامل

Large-scale bioprospecting of cyanobacteria, micro- and macroalgae from the Aegean Sea.

Marine organisms constitute approximately one-half of the total global biodiversity, being rich reservoirs of structurally diverse biofunctional components. The potential of cyanobacteria, micro- and macroalgae as sources of antimicrobial, antitumoral, anti-inflammatory, and anticoagulant compounds has been reported extensively. Nonetheless, biological activities of marine fauna and flora of th...

متن کامل

GC- MS analysis and anticancer effect against MCF-7 and HT-29 cell lines and antioxidant, antimicrobial and wound healing activities of plant- derived compounds

Introduction: Antioxidants are compounds that eliminate free radicals, which reduce tissue damage and allow the organs and blood vessels to properly heal. In this research, the anticancer effect against MCF-7 and HT-29 cell lines, and antioxidant, antimicrobial and wound healing activities of the lichens extracts have been investigated. Materials and methods: Anticancer activity was assayed wi...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره 9  شماره 

صفحات  -

تاریخ انتشار 2018